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Elements of the quality target product profile (QTPP), their targets and justification.
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Elements of the quality target product profile (QTPP), their targets and justification.

Journal: Pharmaceutics

Article Title: Quality by Design Based Formulation Study of Meloxicam-Loaded Polymeric Micelles for Intranasal Administration

doi: 10.3390/pharmaceutics12080697

Figure Lengend Snippet: Elements of the quality target product profile (QTPP), their targets and justification.

Article Snippet: Nanocarrier , Polymeric micelles with particle size between 80 and 120 nm with monodisperse distribution , The proper particle characteristics are a critical parameter in absorption from the nasal mucosa exploiting the “nose-to-brain” pathway. Furthermore, increase in specific surface area and decrease in size contributes to higher water solubility, leading to faster dissolution..

Techniques: Activity Assay, Dissolution, Permeability, Solubility